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Case Reports
Treatment of membranous nephropathy with crescent nephritis by rituximab: A case report.
- Fan Zhang, Yiya Yang, Yinyin Chen, Ying Chen, Wei Yin, Yumei Liang, and Xun Luo.
- Department of Nephrology and Laboratory of Kidney Disease, Hunan Provincial People's Hospital, Hunan Normal University, Changsha, China.
- Medicine (Baltimore). 2022 Sep 16; 101 (37): e30663.
BackgroundCrescent formation is rare in primary membranous nephropathy (MN). The mechanism of crescent formation is unknown and the treatments are tentative.Patient ConcernsA 71-year-old woman presented with nephrotic syndrome, hematuria, and rapidly progressive kidney dysfunction.DiagnosisKidney biopsy was performed, and the diagnosis was MN in combination with crescentic glomerulonephritis. Circulating anti-PLA2R was detected of a high level.InterventionsThe patient received rituximab besides corticosteroids.OutcomesThe patient achieved complete remission of proteinuria and recovery of kidney function.ConclusionOur case suggests that there is a pathologic feature of MN and crescents in the absence of known immunologic factors as well as rituximab could serve as an effective cure and could be considered in serious MN conditions.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
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