• Vitoria Carneiro de Mattos, Fernanda Sayuri do Nascimento, Milena Oliveira Suzuki, João Victor Taba, Leonardo Zumerkorn Pipek, Walter Augusto Fabio Moraes, Vitor Santos Cortez, Márcia Saldanha Kubrusly, Matheus Belloni Torsani, Leandro Iuamoto, Wu Tu Hsing, Luiz Augusto Carneiro-D'Albuquerque, Alberto Meyer, and Wellington Andraus.
• Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
• Clinics (Sao Paulo). 2022 Jan 1; 77: 100101100101.

IntroductionThe increase in the incidence of pancreatic and biliary cancers has attracted the search for methods of early detection of diseases and biomarkers. The authors propose to analyze new findings on the association between microbiota and Pancreatic Ductal Adenocarcinoma (PDAC) or Cholangiocarcinoma (CCA).MethodsThis systematic review was carried out according to the items of Preferred Reports for Systematic Reviews and Protocol Meta-Analysis (PRISMA-P). This study was registered by the Prospective Register of Systematic Reviews (PROSPERO), identification code CRD42020192748 before the review was carried out. Articles were selected from the PUBMED, EMBASE, and Cochrane databases.ResultsMost studies (86.67%) used 16s rRNA as a sequencing method. The main comorbidities found were diabetes mellitus, systemic arterial hypertension, and dyslipidemia. Many studies were limited by the small number of participants, but the biases were mostly low. There was very little concordance about the composition of the microbiome of different sites, for both case and control groups when compared to other studies' results. Bile sample analysis was the one with a greater agreement between studies, as three out of four studies found Escherichia in cases of CCA.ConclusionThere was great disagreement in the characterization of both the microbiota of cases and control groups. Studies are still scarce, making it difficult to adequately assess the data in this regard. It was not possible to specify any marker or to associate any genus of microbiota bacteria with PDAC or CCA.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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