• Patrick Spraider, Judith Martini, Julia Abram, Gabriel Putzer, Manuela Ranalter, Simon Mathis, Tobias Hell, Tom Barnes, and Dietmar Enk.
• From the Department of Anaesthesia and Intensive Care Medicine, Medical University Innsbruck, Austria (PS, JM, JA, GP, MR, SM), Department of Mathematics, Faculty of Mathematics, Computer Science and Physics, University of Innsbruck, Austria (TH), University of Greenwich, UK (TB), Faculty of Medicine, University of Münster, Germany (DE).
• Eur J Anaesthesiol. 2022 Nov 1; 39 (11): 885894885-894.

BackgroundFlow-controlled ventilation (FCV) enables precise determination of dynamic compliance due to a continuous flow coupled with direct tracheal pressure measurement. Thus, pressure settings can be adjusted accordingly in an individualised approach.ObjectiveThe aim of this study was to compare gas exchange of individualised FCV to pressure-controlled ventilation (PCV) in a porcine model of simulated thoracic surgery requiring one-lung ventilation (OLV).DesignControlled interventional trial conducted on 16 domestic pigs.SettingAnimal operating facility at the Medical University of Innsbruck.InterventionsThoracic surgery was simulated with left-sided thoracotomy and subsequent collapse of the lung over a period of three hours. When using FCV, ventilation was performed with compliance-guided pressure settings. When using PCV, end-expiratory pressure was adapted to achieve best compliance with peak pressure adjusted to achieve a tidal volume of 6 ml kg -1 during OLV.Main Outcome MeasuresGas exchange was assessed by the Horowitz index (= P aO 2 /FIO 2 ) and CO 2 removal by the P aCO 2 value in relation to required respiratory minute volume.ResultsIn the FCV group ( n  = 8) normocapnia could be maintained throughout the OLV trial despite a significantly lower respiratory minute volume compared to the PCV group ( n  = 8) (8.0 vs. 11.6, 95% confidence interval, CI -4.5 to -2.7 l min -1 ; P  < 0.001), whereas permissive hypercapnia had to be accepted in PCV ( P aCO 2 5.68 vs. 6.89, 95% CI -1.7 to -0.7 kPa; P  < 0.001). The Horowitz index was comparable in both groups but calculated mechanical power was significantly lower in FCV (7.5 vs. 22.0, 95% CI -17.2 to -11.8 J min -1 ; P  < 0.001).ConclusionsIn this porcine study FCV maintained normocapnia during OLV, whereas permissive hypercapnia had to be accepted in PCV despite a substantially higher minute volume. Reducing exposure of the lungs to mechanical power applied by the ventilator in FCV offers a possible advantage for this mode of ventilation in terms of lung protection.Copyright © 2022 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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