• Marta Sagastagoitia-Fornie, Eduardo Barge-Caballero, Gonzalo Barge-Caballero, David Couto-Mallón, María J Paniagua-Martín, Daniel Enríquez-Vázquez, Paula Blanco-Canosa, Zulaika Grille-Cancela, Manuel Jiménez-Navarro, Javier Muñiz, José M Vázquez-Rodríguez, and María G Crespo-Leiro.
• Servicio de Cardiología, Hospital Universitario Arquitecto Marcide, Ferrol (A Coruña), Spain.
• Eur. J. Intern. Med. 2022 Nov 1; 105: 89-96.

AimsTo assess the incidence of cancer diagnosis and cancer-related mortality in patients with heart failure (HF).MethodsObservational study based in a prospective cohort of patients with HF referred to a specialized Spanish clinic between 2010 and 2019. The observed incidence of malignancies (excluding non-melanoma skin cancer) was compared to that expected for the general Spanish population according to the Global Cancer Observatory.ResultsWe studied 1909 consecutive patients with HF. Over a median follow-up of 4.07 years, 165 new cases of malignancy were diagnosed. Observed age-standardized incidence rates of cancer were 861 (95% CI 618.4-2159.4) cases per 100,000 patients-years in men and 728.5 (95% CI 451.1-4308.7) cases per 100,000 patients-years in women; while age-standardized incidence rates of cancer expected for the general Spanish population were 479.4 cases per 100,000 patients-years in men (risk ratio = 1.80) and 295.5 cases per 100,000 patients-years in women (risk ratio = 2.46). Both a history of pre-existing malignancy at baseline and the development of new malignancies during follow-up were associated with reduced survival. Observed age-standardized cancer-related mortality was 344.1 (95% CI 202.1-1675) deaths per 100,000 patient-years in men and 217.0 (95% CI 32.8-3949.3) deaths per 100,000 patient-years in women; while age-standardized cancer-related mortality expected for the general Spanish population was 201.4 deaths per 100,000 patients-years in men (risk ratio = 1.71) and 96.2 deaths per 100,000 patients-years in women (risk ratio = 2.26).ConclusionPatients with HF showed higher incidence rates of cancer diagnosis and cancer-related mortality than those expected for the general population.Copyright © 2022. Published by Elsevier B.V.

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