• Orhan Karayiğit, Serdar Gökhan Nurkoç, Funda Başyiğit, and Emrullah Kızıltunç.
• Department of Cardiology, Yozgat City Hospital, Yozgat, Turkey.
• Med Princ Pract. 2022 Jan 1; 31 (6): 548554548-554.

BackgroundResolvin D1 (RvD1) can play a determining role in inflammatory cell migration and reduce the expression of inflammatory cytokines to enhance cardioprotection. The aim of this study was to compare serum RvD1 levels in patients with ST-segment elevation myocardial infarction (STEMI) and individuals with normal coronary arteries (NCAs) and to evaluate the association between serum RvD1 levels and prognostic markers of STEMI.Methods140 subjects (88 patients diagnosed with the indication of STEMI and 52 healthy individuals with NCA) were studied.ResultsRegression analysis revealed that RvD1 levels were independently associated with STEMI. While RvD1 levels were negatively correlated with high-sensitivity C-reactive protein, pro-brain natriuretic peptide, peak troponin, and Thrombolysis in Myocardial Infarction thrombus grade, they were positively correlated with left ventricular ejection fraction. An RvD1 cut-off value of 5.07 (ng/mL) was effective in predicting STEMI with a sensitivity of 79.5% and specificity of 96.2%.ConclusionSerum RvD1 levels were found to be lower in the group with STEMI compared to the control group. Levels of RvD1 at admission were associated with poor prognostic markers of STEMI.© 2022 The Author(s). Published by S. Karger AG, Basel.

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