• Am. J. Med. · Jan 2023

    Review

    Multiple Myeloma for the Primary Care Provider: A Practical Review to Promote Earlier Diagnosis Among Diverse Populations.

    • Joseph Mikhael, Manisha Bhutani, and Craig E Cole.
    • Applied Cancer Research and Drug Discovery Division, Translational Genomics Research Institute (TGen), City of Hope Cancer Center, Phoenix, Ariz; International Myeloma Foundation, Studio City, Calif. Electronic address: jmikhael@myeloma.org.
    • Am. J. Med. 2023 Jan 1; 136 (1): 334133-41.

    AbstractMultiple myeloma is the second most common hematologic malignancy in the United States and the most common hematologic malignancy among Blacks/African Americans. Delay in diagnosis is common and has been associated with inferior disease-free survival and increased rates of myeloma-related complications. Despite a roughly 2-times higher risk of multiple myeloma, diagnostic delay appears more common, and improvements in 5-year survival rates have been slower among Blacks/African Americans than their White counterparts. When patient symptoms and basic laboratory findings are suggestive of multiple myeloma, the primary care provider should initiate extended laboratory work-up that includes serum protein electrophoresis, serum immunoglobulin free light chain assay, and serum immunofixation. Heightened awareness within high-risk populations such as Blacks/African Americans may help to eliminate racial disparities in the diagnosis and treatment of multiple myeloma.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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