• Timothy J Yee, Cheerag Upadhyaya, Domagoj Coric, Eric A Potts, Erica F Bisson, Jay Turner, Jack J Knightly, Kai-Ming Fu, Kevin T Foley, Luis Tumialan, Mark E Shaffrey, Mohamad Bydon, Praveen Mummaneni, Dean Chou, Andrew Chan, Scott Meyer, Anthony L Asher, Christopher Shaffrey, Oren N Gottfried, Khoi D Than, Michael Y Wang, Avery L Buchholz, Regis Haid, and Paul Park.
• Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
• Neurosurgery. 2022 Dec 1; 91 (6): 952960952-960.

BackgroundThe modified Japanese Orthopedic Association (mJOA) score is a widely used and validated metric for assessing severity of myelopathy. Its relationship to functional and quality-of-life outcomes after surgery has not been fully described.ObjectiveTo quantify the association of the mJOA with the Neck Disability Index (NDI) and EuroQol-5 Dimension (EQ-5D) after surgery for degenerative cervical myelopathy.MethodsThe cervical module of the prospectively enrolled Quality Outcomes Database was queried retrospectively for adult patients who underwent single-stage degenerative cervical myelopathy surgery. The mJOA score, NDI, and EQ-5D were assessed preoperatively and 3 and 12 months postoperatively. Improvement in mJOA was used as the independent variable in univariate and multivariable linear and logistic regression models.ResultsAcross 14 centers, 1121 patients were identified, mean age 60.6 ± 11.8 years, and 52.5% male. Anterior-only operations were performed in 772 patients (68.9%). By univariate linear regression, improvements in mJOA were associated with improvements in NDI and EQ-5D at 3 and 12 months postoperatively (all P < .0001) and with improvements in the 10 NDI items individually. These findings were similar in multivariable regression incorporating potential confounders. The Pearson correlation coefficients for changes in mJOA with changes in NDI were -0.31 and -0.38 at 3 and 12 months postoperatively. The Pearson correlation coefficients for changes in mJOA with changes in EQ-5D were 0.29 and 0.34 at 3 and 12 months.ConclusionImprovements in mJOA correlated weakly with improvements in NDI and EQ-5D, suggesting that changes in mJOA may not be a suitable proxy for functional and quality-of-life outcomes.Copyright © Congress of Neurological Surgeons 2022. All rights reserved.

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