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- Asami Munekane, Yutaka Ohsawa, Mariko Okubo, Taiji Nagai, Hirotake Nishimura, Ichizo Nishino, and Yoshihide Sunada.
- Department of Neurology, Kawasaki Medical School, Japan.
- Intern. Med. 2023 May 1; 62 (9): 134513491345-1349.
AbstractBecker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis. Notably, the patient had an elevated serum anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody level. Oral glucocorticoid and methotrexate treatment partially improved the muscle weakness with decreased levels of serum creatine kinase. An accurate diagnosis is important for therapeutic decisions in these complicated cases.
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