• Internal medicine · Apr 2023

    Review Case Reports

    A Case of a Pregnant Woman with IgA Nephropathy Showing Histological Preeclampsia Findings without Hypertension Treated with Steroids: A Case Report and Literature Review.

    • Nagisa Koda, Kei Matsumoto, Yukio Maruyama, Naomi Ishikawa, Nobuo Tsuboi, Tetsuya Kawamura, and Takashi Yokoo.
    • Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
    • Intern. Med. 2023 Apr 15; 62 (8): 119512021195-1202.

    AbstractA 35-year-old woman pregnant with twins developed nephrotic syndrome (NS) at 33 weeks' gestation, but her blood pressure remained within the normal range throughout gestation and puerperium. At 34 weeks' gestation, she delivered healthy twins via Caesarean section. After delivery, she developed massive proteinuria (21.1 g/day) and severe hypoalbuminemia (1.0 g/dL). A renal biopsy performed 19 days after delivery revealed IgA nephropathy (IgAN) and preeclampsia. She was treated with steroids, and the NS gradually resolved. This is a rare case of massive gestational proteinuria with IgAN and preeclampsia pathologically that did not meet the clinical criteria for preeclampsia.

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