• Jasper M Smit, Lotte Exterkate, Arne J van Tienhoven, Mark E Haaksma, Micah L A Heldeweg, Lucas Fleuren, Patrick Thoral, Tariq A Dam, HeunksLeo M ALMADepartment of Intensive Care, Erasmus Medical Center, Rotterdam, the Netherlands., Diederik Gommers, Olaf L Cremer, Rob J Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Alexander P Vlaar, Dave A Dongelmans, Remko de Jong, Marco Peters, Marlijn J A Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G C A Nooteboom, Wouter de Ruijter, Louise C Urlings-Strop, SmitEllen G MEGMIntensive Care, Spaarne Gasthuis, Haarlem en Hoofddorp, the Netherlands., D Jannet Mehagnoul-Schipper, Tom Dormans, de JagerCornelis P CCPCDepartment of Intensive Care, Jeroen Bosch Ziekenhuis, Den Bosch, the Netherlands., Stefaan H A Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C Reidinga, Barbara Festen-Spanjer, Gert B Brunnekreef, Alexander D Cornet, Walter van den Tempel, Age D Boelens, Peter Koetsier, Judith Lens, Harald J Faber, A Karakus, Robert Entjes, Paul de Jong, RettigThijs C DTCDDepartment of Anesthesiology, Intensive Care and Pain Medicine, Amphia Ziekenhuis, Breda, the Netherlands., Sesmu Arbous, Bas Vonk, Tomas Machado, GirbesArmand R JARJDepartment of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Medical Data Science (AMDS), Amsterdam Institute for Infection and Immunity (AII) and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, Vrije , Elske Sieswerda, ElbersPaul W GPWGDepartment of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Medical Data Science (AMDS), Amsterdam Institute for Infection and Immunity (AII) and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, Vrije Un, and Pieter R Tuinman.
• Department of Intensive Care Medicine, Research VUmc Intensive Care (REVIVE), Amsterdam Medical Data Science (AMDS), Amsterdam Institute for Infection and Immunity (AII) and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
• Shock. 2022 Nov 1; 58 (5): 358365358-365.

AbstractBackground: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.Copyright © 2022 by the Shock Society.

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