• Hiraku Sedogawa, Norihiro Watanabe, Yoshikazu Hirose, Naoko Mizouchi, Shunri Shimagaki, Hiroki Yamaguchi, and Yasuo Hirose.
• Department of Emergency and Critical Care Medicine, Niigata City General Hospital, Niigata, Japan.
• Medicine (Baltimore). 2022 Sep 30; 101 (39): e30884e30884.

IntroductionLevetiracetam is a newer second-generation anticonvulsant for the treatment of generalized and partial seizure disorders. Common adverse effects are rhabdomyolysis and neuropsychiatric problems, such as somnolence, dizziness, and mood changes. The present report describes the first case, to our knowledge, of levetiracetam overdose resulting in acute kidney injury for which hemodialysis was required.Patient ConcernsA 51-year-old man presented with hypotension and disturbance of consciousness with subsequent development of oliguria and elevated creatinine. Based on his history of ingesting a large dose of levetiracetam and the course of the disease, he was considered to have been poisoned by levetiracetam.DiagnosisAcute kidney injury induced by levetiracetam poisoning.Interventions/OutcomesDialysis was performed for the rapidly progressing renal failure. His renal function improved, and he was weaned from dialysis and discharged home on the 19th day.ConclusionWe should be aware of the possibility that severe renal function deterioration may occur in some patients with levetiracetam overdose. It is possible that clinicians underestimate the occurrence of this problem. In cases of acute renal failure in levetiracetam poisoning, induction of dialysis is beneficial.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

24 keywords...

hide…