• Internal medicine · May 2023

    Case Reports

    Schnitzler Syndrome Presenting as a Fever of Unknown Origin with Elevated Alkaline Phosphatase Levels.

    • Yasuhiro Kano and Makoto Sugihara.
    • Department of General Internal Medicine, Tokyo Metropolitan Tama Medical Center, Japan.
    • Intern. Med. 2023 May 1; 62 (9): 136113641361-1364.

    AbstractSchnitzler syndrome (SchS) is a rare, acquired, autoinflammatory disease that is sometimes associated with a fever of unknown origin (FUO). Elevated alkaline phosphatase (ALP) stemming from abnormal bone remodeling is a characteristic laboratory finding of SchS and is included in the diagnostic criteria. However, its utility as a clue to the diagnosis of SchS has been under-emphasized. We herein report a case of SchS presenting with a FUO and highly elevated ALP concentration, which led to repeated, unnecessary liver biopsies.

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