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- Yasuhiko Koga, Seishi Yoshimi, Takashi Harada, Satoshi Suzuki, Takayuki Ohtsuka, Kunio Dobashi, and Takeshi Hisada.
- Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Japan.
- Intern. Med. 2023 May 15; 62 (10): 155315561553-1556.
AbstractThe efficacy of benralizumab, as well as mepolizumab, to granulomatosis with polyangiitis (EGPA) involved with mononeuritis multiplex remains unclear. We experienced a case of EGPA presenting neuropathy with severe asthma. Muscle weakness due to neuropathy involved with gait disturbance was partly ameliorated by intravenous immunoglobulin therapy. Mepolizumab (100 mg/day) did not promote further improvement of neuropathy. However, the administration of benralizumab instead of mepolizumab improved neuropathy quickly and enabled walking alone. The efficacy of benralizumab for EGPA and its complication has been maintained for over four years. Benralizumab may be a possible treatment for EGPA presenting neuropathy with severe asthma.
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