-
- Xin Zhang, Qing Shi, Lu Xiong, Shiye Shi, Yong Li, Yanhuan Wang, and Mingchuan Zhang.
- Respiratory Department, ChongQing TongLiang People's Hospital, ChongQing, China.
- Clinics (Sao Paulo). 2022 Jan 1; 77: 100102.
ObjectiveThis study aimed to examine changes in miRNAs expression profile of COPD patients.MethodsThirty-six COPD patients as well as thirty-three healthy volunteers were recruited. Total RNAs were collected from the plasma of each participant. The differentially expressed miRNAs in COPD were screened from the GEO database. RT-qPCR was carried out to detect miRNA expression.ResultsIn total, 9 out of 55 miRNAs were expressed differentially in COPD patients. Confirmed by RT-qPCR validation, 6 miRNAs increased while 3 miRNAs decreased. Further analysis of miR-423-5p, which has not been reported in COPD, showed that AUC for the diagnosis of COPD was 0.9651, and miR-423-5p levels was inversely correlated with the duration of smoking.ConclusionThe present study demonstrates that miR-423-5p is a potential marker for identifying COPD patients.Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..