• Suet Li Hooi, Jacky Dwiyanto, Haikel Rasiti, Kai Yee Toh, WongReuben Kong MinRKM0000-0002-6653-6241Yong Loo Lin School of Medicine, National University of Singapore, Singapore.Gastroenterology, gutCARE, Singapore., and Jonathan Wei Jie Lee.
• Data Science, AMILI Pte. Ltd., Singapore.
• Curr Med Res Opin. 2022 Nov 1; 38 (11): 197719821977-1982.

BackgroundRecent studies demonstrate the association of the gut microbiome in regulating interactions between the central nervous system and intestinal function. Individuals with attention-deficit hyperactivity disorder (ADHD) have been shown to have unique gut microbial signature, with depletion of beneficial commensal microbes. Fecal microbiota transplant (FMT) restores the imbalanced gut microbiome and may replete missing microbes to increase production of hormones and neurotransmitters regulating human behavior and cognition.Research Design & MethodsHere, we present an interesting case of a 22-year-old woman treated with FMT primarily to treat recurrent Clostridioides difficile infection, which coincidentally alleviated her ADHD symptoms. We also present the pre- and post-FMT gut microbiota profiles conducted using shotgun metagenomic sequencing on the patient's fecal samples to thereby highlight potential microbial-associated mechanisms associated with the relief of ADHD symptoms.Results & ConclusionsOur case report provides preliminary evidence regarding the use of FMT in a patient with C. difficile and ADHD. We speculate that gut microbiome modulation, in particular the gain or loss of specific microbial species and pathways involving the metabolism of SCFAs, tryptophan and GABA, may merit further exploration as a potential therapeutic strategy for ADHD.

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