• Inmaculada Casas and Francisco Pozo.
• Laboratorio de Virus Respiratorios y Gripe, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España. icasas@iscii.es
• Enferm. Infecc. Microbiol. Clin. 2005 Aug 1;23(7):438-47, quiz 448.

AbstractBeginning in the 1950s respiratory viruses have been gradually discovered by isolation in cell cultures The last were the coronaviruses in the 1960s. No new respiratory viruses were discovered until 2001 when human metapneumovirus was found in respiratory specimens from children with bronchiolitis. A year later, in November 2002, severe acute respiratory syndrome (SARS) suddenly appeared as atypical pneumonia. A novel virus belonging to the Coronaviridae family was found to be a cause of this infection. In 2004, a second coronavirus was discovered (CoV-NL63) and in 2005 a third new coronavirus was described (CoV-HKU1). In addition, several subtypes of the influenza A virus, previously known to infect only poultry and wild birds, were recently found to have been directly transmitted to humans. Respiratory infection has been a considerable problem for humans for centuries. Now, in the 21st century, with new associated viruses continuously emerging, it remains an important field for work.

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