• Int J Med Sci · Jan 2022

    Luteolin Reduces Aqueous Extract PM2.5-induced Metastatic Activity in H460 Lung Cancer Cells.

    • Hui-Wen Lin, Ting-Jing Shen, Nae-Cherng Yang, Meilin Wang, Wen-Che Hsieh, Chen-Ju Chuang, Chane-Yu Lai, and Yuan-Yen Chang.
    • Department of Optometry, Asia University, Taichung, Taiwan.
    • Int J Med Sci. 2022 Jan 1; 19 (10): 1502-1509.

    AbstractFine particulate matter (PM2.5) is the critical cause of lung cancer and can further promote tumor cell migration and invasion. This study investigated the effects of luteolin, an antiangiogenic flavonoid agent, on blocking aqueous extract PM2.5-prompted cancer progression. We observed that luteolin reduced cell migration and the expression of pro-metastatic factors pro-matrix metalloproteinase (MMP)-2 and intercellular adhesion molecule (ICAM)-1 in PM2.5-exposed H460 lung cancer cells. Luteolin treatment also reduced the transduction of PM2.5-induced epidermal growth factor receptor (EGFR)-phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) cascade signaling. Furthermore, the reduction of MMP-2 expression and ICAM-1 production by luteolin in PM2.5-stimulated H460 cells is EGFR-PI3K-AKT pathway dependent. These results suggest that luteolin exhibits antitumor progression by inhibiting EGFR-PI3K-AKT pathway.© The author(s).

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