• Martin Ruste, Raouf Sghaier, Delphine Chesnel, Léa Didier, Jean-Luc Fellahi, and Matthias Jacquet-Lagrèze.
• Service d'anesthésie-réanimation, Hôpital Louis Pradel, Hospices Civils de Lyon, 59, Boulevard Pinel, 69677 Bron Cedex, France; Faculté de médecine Lyon Est, Université Claude Bernard Lyon 1, 8, Avenue Roc... more kefeller, 69373 Lyon, Cedex 08, France. Electronic address: martin.ruste@chu-lyon.fr. less
• J Crit Care. 2022 Dec 1; 72: 154169154169.

BackgroundActive fluid removal has been suggested to improve prognosis following the resolution of acute circulatory failure. We have implemented a routine care protocol to guide fluid removal during continuous renal replacement therapy (CRRT). We designed a before-after pilot study to evaluate the impact of this deresuscitation strategy on the fluid balance.MethodsConsecutive ICU patients suffering from fluid overload and undergoing CRRT for acute kidney injury underwent a perfusion-based deresuscitation protocol combining a restrictive intake, net ultrafiltration (UFnet) of 2 mL/kg/h, and monitoring of perfusion (early dry group, N = 42) and were compared to a historical group managed according to usual practices (control group, N = 45). The primary outcome was the cumulative fluid balance at day 5 or at discharge.ResultsAdjusted cumulative fluid balance was significantly lower in the early dry group (median [IQR]: -7784 [-11,833 to -2933] mL) compared to the control group (-3492 [-9935 to -1736] mL; p = 0.04). The difference was mainly driven by a greater daily UFnet (31 [22-46] mL/kg/day vs. 24 [15-32] mL/kg/day; p = 0.01). There was no significant difference between both groups regarding hemodynamic tolerance.ConclusionOur perfusion-based deresuscitation protocol achieved a greater negative cumulative fluid balance compared to standard practices and was hemodynamically well tolerated.Copyright © 2022 Elsevier Inc. All rights reserved.

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