• Xiaoxu San, Zhiguo Lv, Peng Xu, Jian Wang, and Tianye Lan.
• School of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Jingyue National High-Tech Industrial Development Zone, Changchun, Jilin, China.
• Medicine (Baltimore). 2022 Sep 23; 101 (38): e30606.

PurposeThe objectives of this study were to determine the preventive effects of statins on stroke.MethodsThe published randomized controlled trials of statins for stroke prevention were searched from PubMed, EMBASE, Cochrane Library, and China Journal databases. We performed the meta-analysis via calculating the odds ratio (OR) and 95% confidence interval (CI) to study the mortality rate, incidence, and recurrence rate of patients with stroke in the prevention group and the control group. Chi-square-based Q test and I2 statistics were performed to test the potential heterogeneity; we conducted the sensitivity analysis to assess the stability of our analysis. Moreover, we performed the Begg and Egger tests to assess the publication bias.ResultsNine studies were included to perform meta-analysis, which included 15,497 patients (prevention group [n = 4114]; control group [n = 11383]). We found that the statins were not associated with the patients with stroke in mortality rate (OR = 1.00, 95% CI [0.82, 1.23]) and incidence (OR = 0.94, 95% CI [0.46, 1.92]) between the 2 groups. However, there was a significant differences in recurrence rate between the 2 groups (OR = 0.31, 95% CI [0.19, 0.51]).ConclusionsOur findings indicated that the statins were associated with the patients with stroke in recurrence rate, but there was no significant correlation with the mortality and morbidity of patients with stroke.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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