• Internal medicine · Jan 2022

    Case Reports

    Antineutrophil Cytoplasmic Antibody-associated Vasculitis after COVID-19 Vaccination with Pfizer-BioNTech.

    • Minami Suzuki, Yuta Sekiguchi, Masato Sasaki, Shunsuke Inaba, Sakino Oyama, Yuichi Inoue, Masahiro Warabi, Kenichi Ohashi, and Seiji Inoshita.
    • Department of Nephrology, Tokyo Metropolitan Bokutoh Hospital, Japan.
    • Intern. Med. 2022 Jan 1; 61 (19): 2925-2929.

    AbstractThe extent of rare side effects of mRNA vaccines for coronavirus disease 2019 (COVID-19) remains unclear. Several cases of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) following COVID-19 vaccination have been reported. We herein report a 72-year-old man who presented with a fever after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. He was diagnosed with acute kidney injury due to myeloperoxidase-ANCA-associated vasculitis and was treated with intermittent hemodialysis, high-dose prednisolone, and intravenous rituximab. His general symptoms and renal impairment subsequently improved. When systemic symptoms are prolonged or renal abnormalities appear after COVID-19 vaccination, the possibility of AAV should be considered.

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