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Case Reports
Large-cell Neuroendocrine Carcinoma of the Lung with Carcinoid Syndrome: A Case Report.
- Makoto Yamamoto, Renma Ito, Akihiko Tsujibata, Hiroko Morita, Taro Yoneda, Yutaka Matano, and Toshinori Higashikata.
- Department of Internal Medicine, Komatsu Municipal Hospital, Japan.
- Intern. Med. 2023 May 15; 62 (10): 155715631557-1563.
AbstractA 76-year-old woman was admitted to our hospital for refractory diarrhea with a poor antidiarrheal effect. Chest and abdominal computed tomography revealed a 24×22-mm mass in the left upper lobe of lung and multiple masses in the liver. Urine 5-Hydroxy indol acetic acid was markedly elevated. A liver biopsy revealed large-cell neuroendocrine carcinoma with serotonin production, suggestive of a lung origin, and a lung biopsy revealed combined large-cell neuroendocrine carcinoma and squamous cell carcinoma. Therefore, we made a definitive diagnosis of carcinoid syndrome caused by large-cell neuroendocrine carcinoma of the lung. Although chemotherapy was performed after diagnosis, the patient died 50 days postadmission.
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