• Crit Care · Oct 2022

    Review

    Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions.

    • Martin S Winkler, Marcin F Osuchowski, Didier Payen, Antoni Torres, Steffen Dickel, and Tomasz Skirecki.
    • Department of Anaesthesiology and Intensive Care Medicine, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. martin.winkler@med.uni-goettingen.de.
    • Crit Care. 2022 Oct 8; 26 (1): 308.

    AbstractThe 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established. This may constitute a harbinger of a wider use of GCs in critical illnesses. A fundamental prerequisite of such an action is a better understanding of the heterogeneity of critical illness and GCs operationalization within the precision medicine approach. In this perspective, we formulate ten major questions regarding the use of GCs in critical illness. Answering them will likely facilitate a new era of effective and personalized GCs use in modern critical care.© 2022. The Author(s).

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