• Halil İbrahim Biter, Muhsin Kalyoncuoğlu, Aydın Rodi Tosu, Sinem Çakal, Ziya Apaydın, Ayça Gümüşdağ, Tufan Çınar, Ferhat Eyüpkoca, Erdal Belen, and Mehmet Mustafa Can.
• Health Sciences University, Sultangazi Haseki Training and Research Hospital, Department of Cardiology - Istanbul, Turkey.
• Rev Assoc Med Bras (1992). 2022 Sep 1; 68 (9): 1297-1302.

ObjectiveThe purpose of this study was to explore the efficacy of the triglyceride glucose (TyG) index on in-hospital mortality in nondiabetic coronavirus disease 2019 (COVID-19) patients with myocardial injury.MethodsThis was a retrospective study, which included 218 nondiabetic COVID-19 patients who had myocardial injury. The TyG index was derived using the following equation: log [serum triglycerides (mg/dL) ×fasting blood glucose (mg/dL)/2].ResultsOverall, 49 (22.4%) patients died during hospitalization. Patients who did not survive had a higher TyG index than survivors. In multivariate Cox regression analysis, it was found that the TyG index was independently associated with in-hospital death. A TyG index cutoff value greater than 4.97 was predicted in-hospital death in nondiabetic COVID-19 patients with myocardial damage, with 82% sensitivity and 66% specificity. A pairwise evaluation of receiver operating characteristic (ROC) curves demonstrated that the TyG index (AUC: 0.786) had higher discriminatory performance than both triglyceride (AUC: 0.738) and fasting blood glucose (AUC: 0.660) in predicting in-hospital mortality among these patients.ConclusionsThe TyG index might be used to identify high-risk nondiabetic COVID-19 patients with myocardial damage.

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