• Archana Sharma-Oates, Dawit T Zemedikun, Kanta Kumar, John A Reynolds, Avinash Jain, Karim Raza, John A Williams, Laura Bravo, Victor Roth Cardoso, Georgios Gkoutos, Krishnarajah Nirantharakumar, and Janet M Lord.
• Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK. a.sharma-oates@bham.ac.uk.
• Bmc Med. 2022 Oct 13; 20 (1): 346346.

BackgroundThe prevalence of some immune-mediated diseases (IMDs) shows distinct differences between populations of different ethnicities. The aim of this study was to determine if the age at diagnosis of common IMDs also differed between different ethnic groups in the UK, suggestive of distinct influences of ethnicity on disease pathogenesis.MethodsThis was a population-based retrospective primary care study. Linear regression provided unadjusted and adjusted estimates of age at diagnosis for common IMDs within the following ethnic groups: White, South Asian, African-Caribbean and Mixed-race/Other. Potential disease risk confounders in the association between ethnicity and diagnosis age including sex, smoking, body mass index and social deprivation (Townsend quintiles) were adjusted for. The analysis was replicated using data from UK Biobank (UKB).ResultsAfter adjusting for risk confounders, we observed that individuals from South Asian, African-Caribbean and Mixed-race/Other ethnicities were diagnosed with IMDs at a significantly younger age than their White counterparts for almost all IMDs. The difference in the diagnosis age (ranging from 2 to 30 years earlier) varied for each disease and by ethnicity. For example, rheumatoid arthritis was diagnosed at age 49, 48 and 47 years in individuals of African-Caribbean, South Asian and Mixed-race/Other ethnicities respectively, compared to 56 years in White ethnicities. The earlier diagnosis of most IMDs observed was validated in UKB although with a smaller effect size.ConclusionIndividuals from non-White ethnic groups in the UK had an earlier age at diagnosis for several IMDs than White adults.© 2022. The Author(s).

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