• World Neurosurg · Mar 2023

    Meta Analysis

    Complications of Deep Brain Stimulation for Parkinson's Disease and Relationship of Micro-Electrode Tracks on Hemorrhage: Systematic Review and Meta-analysis.

    • Neilen P Rasiah, Romir Maheshwary, Churl-Su Kwon, Joshua D Bloomstein, and Fady Girgis.
    • Department of Neurosurgery, Cumming School of Medicine, University of Calgary, Alberta, USA.
    • World Neurosurg. 2023 Mar 1; 171: e8e23e8-e23.

    BackgroundDeep brain stimulation is a common treatment for Parkinson's disease (PD). Despite strong efficacy in well-selected patients, complications can occur. Intraoperative micro-electrode recording (MER) can enhance efficacy by improving lead accuracy. However, there is controversy as to whether MER increases risk of hemorrhage.ObjectivesTo provide a comprehensive systematic review and meta-analysis reporting complication rates from deep brain stimulation in PD. We also interrogate the association between hemorrhage and MER.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were implemented while querying the Pubmed, Embase, and Cochrane databases. All included studies were randomized controlled trials and prospective case series with 5 or more patients. Primary outcomes included rates of overall revision, infection, lead malposition, surgical site and wound complications, hardware-related complications, and seizure. The secondary outcome was the relationship between number of MER tracks and hemorrhage rate.Results262 articles with 21,261 patients were included in the analysis. Mean follow-up was 25.8 months (range 0-133). Complication rates were: revision 4.9%, infection 4.2%, lead malposition 3.3%, surgical site complications 2.8%, hemorrhage 2.4%, hardware-related complications 2.4%, and seizure 1.9%. While hemorrhage rate did not increase with single-track MER (odds ratio, 3.49; P = 0.29), there was a significant non-linear increase with each additional track.ConclusionInfection and lead malposition were the most common complications. Hemorrhage risk increases with more than one MER track. These results highlight the challenge of balancing surgical accuracy and perioperative risk.Copyright © 2022 Elsevier Inc. All rights reserved.

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