• Dechen Kong, Xiaotong Dong, Peiyan Qin, Daqing Sun, Zhengtao Zhang, Yan Zhang, Furong Hao, and Mingchen Wang.
• Clinical School, Weifang Medical University, Weifang, China.
• Medicine (Baltimore). 2022 Oct 14; 101 (41): e31061.

RationaleUterine metastasis from breast cancer is extremely rare. Asymptomatic patients with cervical metastases from breast cancer are rarer and more likely to be missed. We present an asymptomatic patient with breast cancer metastasized to the uterus and share opinions on diagnosing and treating for this kind of cases.Patient ConcernsWe present the case of a 64-year-old woman who was diagnosed with both breast cancer and uterine fibroids after examination. She had no symptoms of gynecological disease during breast cancer treatment. A positron emission tomography/computed tomography (PET/CT) scan was performed during reexamination, revealing multiple metastases of the bone throughout the body and an abnormal hypermetabolic mass in the uterus. It was later confirmed as uterine metastasis by pathology.DiagnosisA diagnosis of metastatic breast invasive lobular carcinoma was established after a uterine curettage.Interventions And OutcomesTreatment of the uterine metastasis included systemic chemotherapy, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH and BSO), postoperative radiotherapy, and postoperative chemotherapy. The patient eventually refused further treatment for personal reasons and died at home.LessonsBreast cancer metastases to the uterus are very rare and further research is needed for their diagnosis and treatment. During reexamination of breast cancer patients, clinicians must be alert to metastasis to gynecologic organs. This is particularly important in hormone receptor-positive patients with asymptomatic distant metastasis.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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