• Qiuxiang Wang, Chengjiao Yao, Yilin Li, Lihong Luo, Fengjiao Xie, Qin Xiong, Ruike Wu, Juan Wang, Peimin Feng, and A protocol for systematic review and meta-analysis.
• Chengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu, Sichuan Province, China.
• Medicine (Baltimore). 2022 Oct 14; 101 (41): e30929.

BackgroundThe ongoing coronavirus disease 2019 (COVID-19) pandemic has drastically challenged the safety of on esophageal cancer (EC) surgery during COVID-19. The study aimed to evaluate the safety of EC surgery during the COVID-19 pandemic.MethodsThis systematic review was performed in accordance with the PRISMA-P 2015 guidelines and registered in PROSPERO (registration number: CRD42022335164). A systematic search of PubMed, Embase, Cochrane Library, Web of Science, Medline, Chinese National Knowledge Infrastructure database, Chinese Scientific Journal database, and Wan Fang database was conducted to identify potentially relevant publications from January 2020 to May 2022. All data were independently extracted by two researchers. We will apply a fixed-effect model or random effect model basis on the heterogeneity test and employ with RevMan 5.4.1 software for data synthesis. The dichotomous surgical outcomes used risk ratios or risk differences, and for continuous surgical outcomes, mean differences (MD) or standardized MD, both with 95% confidence intervals were used. The primary outcomes were postoperative complications, anastomotic leaks, and mortality. The secondary outcomes were total hospital stay, postoperative stay, preoperative waiting, operation time, blood loss, transfusion, postoperative intensive care unit (ICU) stay, number of patients needing ICU stay, and 30-day readmission.ResultsThis study will comprehensively summarize the high-quality trials to determine the safety of EC surgery during COVID-19.ConclusionOur systematic review and meta-analysis will present evidence for the safety of EC surgery during COVID-19.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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