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- Kensuke Kanaoka, Shoichi Ihara, Takeshi Nakatani, and Seigo Minami.
- Department of Respiratory Medicine, Osaka Police Hospital, Japan.
- Intern. Med. 2023 Jul 1; 62 (13): 197119751971-1975.
AbstractAnti-glomerular basement membrane (GBM) disease with isolated diffuse alveolar hemorrhage (DAH) is rare. We herein report a 91-year-old man admitted with hypoxia and diagnosed with anti-GBM disease with DAH based on positive bronchoalveolar lavage and serum antibody test results. There was no renal involvement. Although remission was achieved using glucocorticoids and plasmapheresis, the patient experienced DAH relapse one week after the last plasmapheresis. Rituximab 375 mg/m2 was administered 4 times weekly; thereafter, DAH relapse was not observed, and the glucocorticoid dosage was tapered. Rituximab was thus effective in treating anti-GBM disease with isolated DAH in an extremely elderly patient.
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