• Internal medicine · Jun 2023

    Case Reports

    Primary Effusion Lymphoma-like ATL Developing During Hemodialysis.

    • Miharu Masaki, Yuki Okushi, Atsushi Saito, Akihiro Fukuda, Sohsuke Yamada, Shuichi Mizuta, and Yasufumi Masaki.
    • Department of Cardiology, Kanazawa Medical University, Japan.
    • Intern. Med. 2023 Jun 15; 62 (12): 180718111807-1811.

    AbstractWe herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.

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