• Terapevt Arkh · Jul 2021

    Case Reports

    [Repeated haploidentical allogeneic hematopoietic stem cell transplantation with TCR αβ/CD19 depletion in patient with primary myelofibrosis. Case report].

    • E I Kolgaeva, V A Vasilyeva, L A Kuzmina, M Y Drokov, M V Dovydenko, Z V Konova, D I Chebotarev, A M Kovrigina, D V Kamelskih, T V Gaponova, M A Sokolova, I N Subortseva, A L Melikyan, M A Maschan, E N Parovichnikova, and V G Savchenko.
    • National Research Center for Hematology.
    • Terapevt Arkh. 2021 Jul 23; 93 (7): 805-810.

    AbstractIndications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with primary myelofibrosis are intermediate-2 and high-risk group of DIPSS (Dynamic International Prognostic Scoring System), beginning of the disease in childhood. The other adverse factors affect engraftment and survival after allo-HSCT, example partialy matched donor. But the result of allo-HSCT from matched related donors and result of allo-HSCT from haploidentical donors are comparable. The method for haploidentical hematopoietic stem cell transplantation is T-cell-depletion. This is clinical case of T-cell-depleted haploidentical hematopoietic stem cell transplantation in patient with primary myelofibrosis, the diagnosis was established in childhood.

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