• V V Rameev, L V Kozlovskaya, A S Rameeva, A V Novikov, and M V Barsuk.
• Sechenov First Moscow State Medical University (Sechenov University).
• Terapevt Arkh. 2021 Jun 15; 93 (6): 672-678.

AimTo investigate an influence of the currently changed etiologic structure of AA-amyloidosis on the diagnosis and treatment tactics.Materials And MethodsIn 110 patients with АА-amyloidosis followed during full disease duration (1 month 29 years) etiology, clinical manyfestations and approaches to diagnose and treatment of AA-amyloidosis were evaluated. With ELISA levels of amyloid precursor acute phase inflammation reactant SAA and neutrophil activity marker S100A12 were measured.ResultsAmong the most common causes of AA-amyloidosis at the present stage, in addition to RA (40.3%), a significant place is occupied by a group of diseases with a predominantly autoinflammatory mechanism (53.73%). To confirm the autoinflammatory mechanism of the predisposing disease it is recommended to study a highly sensitive parameter serum protein S100A12. An effective marker of the risk of AA-amyloidosis progression, especially in patients with subclinical activity of inflammatory disease, is a high level of production of amyloidogenic protein-a precursor of SAA.

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