• Youseung Chung, Eun Jin Kim, Hee-Sung Kim, Kyung-Hwa Park, Ji Hyeon Baek, Jungok Kim, Ji Yeon Lee, Chang-Seop Lee, Seungjin Lim, Shin-Woo Kim, Eu Suk Kim, Hye Jin Shi, Shin Hee Hong, Jae-Bum Jun, Kyung-Wook Hong, Jae-Phil Choi, Jinyeong Kim, Kyung Sook Yang, and Young Kyung Yoon.
• Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
• J. Korean Med. Sci. 2022 Oct 24; 37 (41): e297.

BackgroundThis study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.MethodsThis multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.ResultsA total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04-1.15) and parity (OR, 1.703, 95% CI, 1.13-2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns' amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.ConclusionAt the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.© 2022 The Korean Academy of Medical Sciences.

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