• Terapevt Arkh · Jun 2021

    [Treatment of thrombotic thrombocytopenic purpura].

    • G M Galstyan, A A Maschan, E E Klebanova, and I I Kalinina.
    • National Research Center for Hematology.
    • Terapevt Arkh. 2021 Jun 15; 93 (6): 736745736-745.

    AbstractThe review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpuгa (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treatment options such as cyclosporin A, bortezomib, splenectomy, N-acetylcysteine, recombinant ADAMTS13 are also described. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.

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