• M A Korolev, E A Letyagina, A E Sizikov, L A Bogoderova, Y B Ubshaeva, V O Omelchenko, A A Akimova, A A Mullagaliev, O A Chumasova, and Y D Kurochkina.
• Research Institute of Clinical and Experimental Lymphology - Branch of Federal Research Center "Institute of Cytology and Genetics".
• Terapevt Arkh. 2022 Jun 17; 94 (5): 636-641.

BackgroundCurrently, observations are accumulating indicating the negative effect of therapy with a number of biologic disease-modifying anti-rheumatic drugs (bDMARDs) drugs on the course of COVID-19. These facts determine the relevance of studying the factors of severe course and unfavorable outcome in immuno-inflammatory rheumatic diseases (IIRD) patients treated with bDMARDs in order to develop tactics for managing this category of patients in a pandemic.AimTo evaluate the influence of clinical and demographic factors on the risk of development, severity of the course and clinical outcomes of a new coronavirus infection in patients suffering from IIRD and receiving therapy with genetically engineered biological drugs.Materials And MethodsA retrospective analysis of the database of the register of patients with IIRD receiving bDMARDs in the Novosibirsk region was performed, which included 318 patients, 94 of whom had indications of having suffered viral infection/pneumonia for the period from 01.04.2020 to 31.12.2020.ResultsAccording to the data obtained, at the time of the analysis, 94 people out of 318 patients with IIRD had a new coronavirus infection. Most (53%) of the patients had a mild infection. At the same time, the nosological form, the use of anti-rheumatic drugs and glucocorticoids did not increase the risks of severe coronavirus infection. When using bDMARDs, only anti-B-cell therapy (rituximab) associated with statistically significant increase in the risk of severe/extremely severe COVID-19. The mortality rate according to the analysis of the register was 6,38%.ConclusionPatients with IIRD have a high risk of severe coronavirus infection, while the severity of the disease is associated with the type of therapy performed.

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