• Ruoxi Li, Wenli Zhao, Hongwu Wang, Maeda Toshiyoshi, Ye Zhao, and Huaien Bu.
• Graduate School, Shandong University of Traditional Chinese Medicine, Jinan, China.
• Medicine (Baltimore). 2022 Oct 21; 101 (42): e31289e31289.

BackgroundTo systematically review and meta-analyze the efficacy of vitamin A as an adjuvant therapy for pneumonia in children.MethodsWe searched in PubMed, the Cochrane Library, Chinese National Knowledge Infrastructure, WanFang Database and Chongqing VIP information network from libraries building to March 2022, screening randomized controlled trials (RCT) about vitamin A combined with conventional therapy for pneumonia in children. Two researchers used the Cochrane risk of bias tool to assess the quality of included studies dependently. Data analysis was conducted in the RevMan 5.3.Results15 trials involving 3496 patients (treated group: 1898; control group: 1598) were analyzed in this study. The Meta-analysis showed that vitamin A combined with conventional therapy improved clinical efficacy (P < .05), shortened the duration of fever and cough, negative time of chest X-ray, and the hospitalization, lung rale disappearance, choking milk disappearance, shortness of breath disappearance and perilabial cyanosis disappearance (P < .05). However, vitamin A combined with conventional therapy did not reduce the mortality of pneumonia in children (P > .05).ConclusionVitamin A contributes to relieve the clinical symptoms and signs, and also shorten the hospitalization.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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