• Segi Kim, Cheungsoo Ha, Ah-Young Kwon, and Wonchul Choi.
• Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Gyeonggi-do, Republic of Korea.
• Medicine (Baltimore). 2022 Oct 21; 101 (42): e31303e31303.

RationaleLipomas are tumors composed of mature adipocytes, originating from the mesoderm, and are the most common soft tissue tumor. According to the World Health Organization classification of human soft tissue and bone tumors, there are 14 types of benign tumors, including mature adipose tissue. Osteolipoma is known as the rarest subtype of lipoma.Patient ConcernsA 63-year-old female presented to our hospital for the evaluation and treatment of a palpable mass with pain in the right knee.DiagnosisThe diagnosis was confirmed as lipoma with osteocartilaginous metaplasia.InterventionsSurgical removal of the tumor was performed.OutcomesThe main symptoms improved immediately after the surgery and recovered without any complications or recurrence until 2 years after surgery.LessonsLipoma with osteochondral degeneration is a rare variant of lipoma and it is important to differentiate it from other malignant tumors. Pathological confirmation should be performed after marginal resection of the mass.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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