• María Roxana Ferreira Sertaje, Marcela Leticia Leal Gonçalves, Andréa Oliver Gomes, Laura Hermida Bruno, Ana Laura Fossati, Natalia Osorio Viarengo, Elaine Marcilio Santos, Ana Paula Taboada Sobral, Raquel Agnelli Mesquita-Ferrari, FernandesKristianne Porta SantosKPSPost Graduation Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, São Paulo, SP, Brazil., HorlianaAnna Carolina Ratto TempestiniACRTPost Graduation Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, São Paulo, SP, Brazil., Lara Jansiski Motta, and Sandra Kalil Bussadori.
• Universidad Católica del Uruguay (UCU), Montevideo, Uruguay.
• Medicine (Baltimore). 2022 Oct 21; 101 (42): e31228e31228.

BackgroundThis study aims to verify if the use of intravascular laser irradiation of blood (ILIB) influences the reduction of pain and increases the range of motion in opening and closing of the mouth in children and adolescents with temporomandibular disorders (TMD).MethodsThis will be a blind, randomized, and controlled clinical trial, which will be carried out on children between 6 and 12 years of age who enter the Catholic University of Uruguay, Faculty of Health Sciences, Postgraduate School, for treatment. To be included, children must present temporomandibular disorders, based on the diagnostic criteria will be the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Forty-five participants will be randomized to three groups: Group 1-ILIB with 2 sessions of 20 minutes for 12 weeks (n = 15); Group 2-Placebo laser application with 2 sessions of 20 minutes for 12 weeks (n = 15); Group 3-Control with no treatment (n = 15). Irradiation will be performed by continuous and direct transcutaneous application to the radial artery, by means of a bracelet that inserts the laser beam. The laser to be used is infrared, power 100 mW ± 20%, wavelength 808 nm ± 10 nm, continuous application. RDC/TMD and pain evaluated through a visual analog scale will be the outcome measures.DiscussionDue to the low level of evidence, new studies are needed on the effect of ILIB in children with TMD.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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