• Ailing Liu, Jing Guo, Hua Liu, Yonghong Xu, Jun Wu, Tao Mao, Zibin Tian, and Xueli Ding.
• Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
• Medicine (Baltimore). 2022 Oct 21; 101 (42): e31213e31213.

RationaleIntestinal stricture and obstruction are rare complications of ulcerative colitis (UC). Currently, there are only a few studies on the treatment of UC with intestinal stenosis, however there are no reports on the treatment of UC with benign intestinal stenosis with ustekinumab (UST).Patient ConcernsA 22-year-old woman was admitted to our hospital due to a 3-year history of recurrent bloody mucous in stool with intermittent abdominal pain and distension developed in the past month. She was steroid-dependent and had developed a secondary loss of response to infliximab.DiagnosesShe was diagnosed with UC combined with incomplete intestinal obstruction due to stenosis. The stricture had a mixed pattern with both inflammatory and fibrotic components, with the former covering a larger section of the intestine.InterventionsThe patient was given UST for 56 weeks.OutcomesThe patient's symptoms subsided after treatment with UST. The ulcers healed, and the stenosis was reduced.LessonsUST is effective against UC with benign intestinal stenosis. It is thought that UST inhibits the production of transforming growth factor-β and interleukin-17, leading to the suppression of myofibroblast proliferation, ultimately alleviating intestinal stenosis.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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