• Haixia Cui, Yuan Huang, Weibo Wen, Xiangdan Li, Dongyuan Xu, and Lan Liu.
• Department of Clinical Laboratory, Yanbian University hospital, Yanji, Jilin Province, China.
• Medicine (Baltimore). 2022 Oct 21; 101 (42): e30745e30745.

BackgroundThe role of the lymph node ratio (LNR) in the existing tumor node metastasis classification system should be verified as one of the prognosis prediction factors. This work evaluated LNR's performance in predicting cervical cancer (CC) prognosis through a meta-analysis.MethodRelated studies were retrieved from the Cochrane Library, EMBASE, and PubMed databases. The language was restricted to English. The combined hazard ratios (HRs) were utilized to analyze the prognostic value of LNR.ResultsOur study included 8 articles with 3325 subjects published after 2015. Based on our analysis, high LNR was the adverse prognostic factor for overall survival (OS, HR = 1.45; 95% CI = 1.23-1.73; P = .238) and disease-free survival (DFS, HR = 2.69; 95% CI = 1.98-3.66; P = .597) among the CC cases. Furthermore, as revealed by subgroup analysis, in CC patients, median LNR of about 0.0625 and 0.066 served as the prominent risk factor for DFS and OS.ConclusionsThe current work illustrates that elevated LNR is related to the dismal prognosis of CC. More well-designed clinical studies are warranted for assessing whether LNR is a factor independently predicting the prognosis of CC.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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