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Case Reports
A Case of Focal Segmental Glomerulosclerosis Associated With Essential Thrombocythemia.
- Hisashi Sugimoto, Naoki Sawa, Hajime Yamagiwa, Masahiro Kawada, Daisuke Ikuma, Yuki Oba, Hiroki Mizuno, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Aya Nishida, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, and Yoshifumi Ubara.
- Nephrology Center and the Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan.
- Intern. Med. 2023 Jun 15; 62 (12): 178917941789-1794.
AbstractA 72-year-old man was admitted for examination of proteinuria (9.14 g/day) and leg edema. Essential thrombocythemia (ET) was diagnosed because of thrombocytosis (platelet count, 57.9×104/μL), elevated megakaryocytes in bone marrow biopsy, and JAK2 V617 mutation. Kidney biopsy led to a diagnosis of focal segmental glomerulosclerosis (FSGS) cellular variant (characterized by glomerular capillaries filled with swollen endothelial cells containing foam cells) in 6 glomeruli, FSGS tip variant in 5 glomeruli, and additional FSGS variants in other glomeruli. Affected glomeruli had anti-CD61 antibody staining-positive megakaryocyte infiltrations. ET mayinduce FSGS because megakaryocyte infiltration increases intraglomerular pressure, resulting in hypertension and proteinuria.
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