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- Munehiro Ikeda, Takashi Tamada, Risa Takebayashi, Gaku Okuno, Iori Yagura, Shohei Nakamori, Taishiro Matsumura, Takuto Yoshioka, Shizuka Kaneko, and Naoki Kanda.
- Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Japan.
- Intern. Med. 2023 Jun 15; 62 (12): 177517791775-1779.
AbstractA 71-year-old woman with recurring stage IV hepatocellular carcinoma (HCC) was admitted to our hospital while being treated with atezolizumab and bevacizumab and complained of fatigue, vomiting, and appetite loss. The following were noted on admission: serum glucose level, 633 mg/dL; metabolic acidemia (HCO3- of 19.5 mmol/L); remarkably low serum and urinary C-peptide levels (0.16 ng/mL and ≤1.5 μg/day, respectively); and urinary ketone body level, 4,197 μmol/L. She was diagnosed with atezolizumab-induced fulminant type 1 diabetes mellitus (T1DM), and insulin therapy improved the symptoms. To our knowledge, this a novel report of atezolizumab-induced fulminant T1DM in an HCC patient.
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