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- Shogo Minomo, Masahiko Ichijo, Fumitaka Shimizu, Ryota Sato, Takashi Kanda, Yoshiki Takai, Tatsuro Misu, Yoshiki Sakurai, Takeshi Amino, and Tomoyuki Kamata.
- Department of Neurology, Musashino Red Cross Hospital, Japan.
- Intern. Med. 2023 Jun 1; 62 (11): 165316571653-1657.
AbstractNeuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.
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