• Yuanming Geng, Zhenxing Li, Junhao Zhu, Chaonan Du, Feng Yuan, Xiangming Cai, Alleyar Ali, Jin Yang, Chao Tang, Zixiang Cong, and Chiyuan Ma.
• Department of Neurosurgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, China.
• J. Neurotrauma. 2023 Jul 1; 40 (13-14): 129713161297-1316.

AbstractInjuries to the central nervous system (CNS) often lead to severe neurological dysfunction and even death. However, there are still no effective measures to improve functional recovery following CNS injuries. Optogenetics, an ideal method to modulate neural activity, has shown various advantages in controlling neural circuits, promoting neural remapping, and improving cell survival. In particular, the emerging technique of optogenetics has exhibited promising therapeutic methods for CNS injuries. In this review, we introduce the light-sensitive proteins and light stimulation system that are important components of optogenetic technology in detail and summarize the development trends. In addition, we construct a comprehensive picture of the current application of optogenetics in CNS injuries and highlight recent advances for the treatment and functional recovery of neurological deficits. Finally, we discuss the therapeutic challenges and prospective uses of optogenetics therapy by photostimulation/photoinhibition modalities that would be suitable for clinical applications.

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