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- Alvise Sernicola, Anna Colpo, Anca Irina Leahu, and Mauro Alaibac.
- Dermatology Unit, Department of Medicine (DIMED), University of Padua, 35122 Padua, Italy.
- Medicina (Kaunas). 2022 Oct 6; 58 (10).
AbstractIn the field of advanced melanoma, there is an urgent need to investigate novel approaches targeting specific components of the cancer-immunity cycle beyond immune checkpoint inhibitors. The authors reviewed the basic understanding of the role of neutrophils in cancer biology, and the latest clinical evidence supporting the correlation between cancer-associated neutrophils and the prognosis and response to the immunotherapy of advanced melanoma. Finally, they propose that granulocyte and monocyte apheresis, an emerging non-pharmacological treatment in current dermatology, could become an investigative treatment targeting melanoma-associated neutrophils which could be potentially used in combination with the usual immune checkpoint inhibitors.
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