• Zhi-Jie Deng, Yu-Feng Ding, Shun-Shun Peng, Lu Wang, and An-Hua Wei.
• Department of Pharmacy, Tongji Hospital, Tongji medical College, Huazhong University of Science and Technology, Wuhan, China.
• Medicine (Baltimore). 2022 Oct 28; 101 (43): e31491e31491.

BackgroundMedication therapy management (MTM) service is an effective method to reduce medication-related problems and improve patients' multiple kinds of outcomes. However, the lack of comprehensive review for MTM services has hindered its development. As a result, we are aiming to evaluate the current benefits of MTM services with multiple outcomes.MethodAn electronic search will be performed for randomized controlled trials (RCTs) or non-randomized control trials (NRCTs) that reported MTM services or pharmaceutical services as interventions from PubMed, The Cochrane Library, Embase, and ClinicalTrial. gov. The odds ratios, mean differences, and standard mean differences and their 95% confidence intervals (95% confidence intervals) will be calculated with fixed or random effect models.ResultsThis study will evaluate the multiple benefits of MTM services in clinical endpoints, quality of life, economy, and drug-related problems.ConclusionThe results will review eligible studies released in the past twenty years and provide more comprehensive evidence of the efficacy of MTM services.Ethics And DisseminationEthical approval is not applicable for this study.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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