• Xiaofang Lu, Jian Li, Shuhan Ye, Runyi Wang, Yao Xiao, Lu Liu, Wanning Lan, Yijun Chen, and Zongli Liao.
• Guangzhou University of Chinese Medicine, Guangzhou, China.
• Medicine (Baltimore). 2022 Oct 28; 101 (43): e31234e31234.

BackgroundDry eye disease (DED) is a condition occurring worldwide. Studies have found that coronavirus disease 2019 (COVID-19) patients may have persistent dry eye symptoms for weeks and months after recovery, and the prevalence of dry eye is higher in COVID-19 patients than in people without COVID-19 infection. As one of the common ophthalmic diseases, the clinical application of acupuncture in the treatment of DED is not widely used nowadays.MethodsAccording to the retrieval strategies, randomized controlled trials (RCT) on the acupuncture for DED after recovery from COVID-19 were obtained from Embase, The Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure database, Chinese Biomedical Database, Chinese Science and Technology Periodical database, The WanFang database. Studies were screened based on inclusion and exclusion criteria, and the Cochrane risk bias assessment tool was used to evaluate the quality of the studies. The meta-analysis was performed using Review Manager (RevMan 5.3) and STATA 14.2 software. Ultimately, the evidentiary grade for the results will be evaluated.ResultsThe study will provide a high-quality and convincing assessment of the efficacy and safety of acupuncture for DED after recovery from COVID-19 and will be published in peer-reviewed journals.ConclusionOur findings will provide references for future clinical decision and guidance development.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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