• Rob Boots, George Xue, Dirk Tromp, Oliver Rawashdeh, Judith Bellapart, Shane Townsend, Michael Rudd, Craig Winter, Gary Mitchell, Nicholas Garner, Pierre Clement, Nermin Karamujic, and Christopher Zappala.
• Rob Boots is an associate professor, Thoracic Medicine, Royal Brisbane and Women's Hospital, a senior specialist, Intensive Care, Bundaberg Hospital, Faculty of Medicine, The University of Queensland, Herston, and a professsor, Faculty of Medicine and Dentistry, Griffith University, Queensland, Australia.
• Am. J. Crit. Care. 2022 Nov 1; 31 (6): 472482472-482.

BackgroundPhysiological functions with circadian rhythmicity are often disrupted during illness.ObjectiveTo assess the utility of circadian rhythmicity of vital signs in predicting outcome of traumatic brain injury (TBI).MethodsA retrospective single-center cohort study of adult intensive care unit (ICU) patients with largely isolated TBI to explore the relationship between the circadian rhythmicity of vital signs during the last 24 hours before ICU discharge and clinical markers of TBI severity and score on the Glasgow Outcome Scale 6 months after injury (GOS-6).ResultsThe 130 study participants had a median age of 39.0 years (IQR, 23.0-59.0 years), a median Glasgow Coma Scale score at the scene of 8.0 (IQR, 3.0-13.0), and a median Rotterdam score on computed tomography of the head of 3 (IQR, 3-3), with 105 patients (80.8%) surviving to hospital discharge. Rhythmicity was present for heart rate (30.8% of patients), systolic blood pressure (26.2%), diastolic blood pressure (20.0%), and body temperature (26.9%). Independent predictors of a dichotomized GOS-6 ≥4 were the Rotterdam score (odds ratio [OR], 0.38 [95% CI, 0.18-0.81]; P = .01), Glasgow Coma Scale score at the scene (OR, 1.22 [95% CI, 1.05-1.41]; P = .008), age (OR, 0.95 [95% CI, 0.92-0.98]; P = .003), oxygen saturation <90% in the first 24 hours (OR, 0.19 [95% CI, 0.05-0.73]; P = .02), serum sodium level <130 mmol/L (OR, 0.20 [95% CI, 0.05-0.70]; P = .01), and active intracranial pressure management (OR, 0.16 [95% CI, 0.04-0.62]; P = .008), but not rhythmicity of any vital sign.ConclusionCircadian rhythmicity of vital signs at ICU discharge is not predictive of GOS-6 in patients with TBI.©2022 American Association of Critical-Care Nurses.

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