• Minerva anestesiologica · Mar 2023

    Randomized Controlled Trial

    Low-intensity transcutaneous auricular vagus nerve stimulation reduces postoperative ileus after laparoscopic radical resection of colorectal cancer: a randomized controlled trial.

    • Ouyang Ru, Xianwei Jin, Liangchao Qu, Dingde Long, Mei Liu, Liqin Cheng, and Yao Jiang.
    • Department of Anesthesiology, the First Affiliated Hospital of Nanchang University, Nanchang, China - ouyangrusmile@163.com.
    • Minerva Anestesiol. 2023 Mar 1; 89 (3): 149156149-156.

    BackgroundPostoperative ileus (POI) is thought to result from a disrupted sympathetic/parasympathetic balance caused by trauma or surgery. Transcutaneous auricular vagus nerve stimulation (tVNS) is a non-invasive technique involving stimulation of the vagal auricular branch, leading to autonomic regulation and reduced inflammation. Here, the effects of low-intensity transcutaneous auricular vagal stimulation on POI after laparoscopic radical resection of colorectal cancer were investigated.MethodsOne hundred and thirty-four patients who received scheduled laparoscopic radical resection of colorectal cancer were randomly allocated to the A and B groups. The A group received low-intensity (25 Hz, 50 mA) transcutaneous electrical stimulation of the right auricular branch for 20 minutes prior to anesthesia while the B group did not. The primary outcome was the incidence of POI.ResultsThe incidence of POI in the A group was 6.25% and 20% in the B group (P=0.022). Patients in the A group showed more regular bowel sounds after 24, 36, and 48 h than those in the B group (P<0.001).ConclusionsLow-intensity transcutaneous auricular vagal stimulation reduced POI after laparoscopic radical resection of colorectal cancer.

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