• Nermin Tepe, Hürrem Evren Boran, Salih Gedük, Ergin Dileköz, İlkay Ulusoy, and Hayrunnisa Bolay.
• Department of Neurology, Balıkesir University Faculty of Medicine, Balıkesir, Turkey. Neuropsychiatry Centre, Gazi University Faculty of Medicine, Ankara, Turkey.
• Turk J Med Sci. 2022 Aug 1; 52 (4): 137113771371-1377.

BackgroundDiscrimination of consecutive sensory stimuli is imperative for proper sensory perception and behavioral response. We aimed to investigate the emergence of paired somatosensory responses in relation to the interstimulus interval (ISI) change.MethodsPaired stimulus with 35 ms, 50 ms, 80 ms, 140 ms, and 500 ms ISI was applied to the median nerve and evoked responses were recorded from the primary somatosensory cortex in rats. Early and late components of both responses were analyzed in different frequency bands.ResultsThe amplitudes were comparable for the 1st responses (S1), while the amplitude of the 2nd responses (S2), and S2/S1 sensory gating ratio were significantly lower at 35 and 50 ms ISI values. S2/S1 ratio was close to 1 at 500 ms ISI. The duration and latency of the 2nd response was also different at 35 ms ISI. In the 2nd responses, area of early high-frequency oscillations (150-400 Hz) was significantly lower at 35 ms ISI values.DiscussionThe shaping of 2nd somatosensory response is dependent on ISIs. Early high-frequency oscillations changes without accompanying late high-frequency oscillations alterations, may indicate that reduced thalamo-cortical drive to the cortex take a part in determining the 2nd response at short ISI. Further research is required by using neuropsychiatric disorder models where somatosensory perception is impaired.

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