• Anthony W Martinelli, William Dunn, Mark E McClure, Ieuan Walker, Andrew Stewart, Sumit Karia, Stephen D Preston, Sathia Thiru, Nicholas Torpey, Sanjay Ojha, Emily Symington, and James A Nathan.
• Department of Respiratory Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, England; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, England. Electronic address: anthony.martinelli@nhs.net.
• Chest. 2022 Nov 1; 162 (5): e245e248e245-e248.

AbstractAlthough sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and hematological sequelae has not been reported. We describe the case of a patient presenting with hypercalcemia, pancreatitis, and acute renal failure, followed by microangiopathic hemolytic anemia. Although there were no significant respiratory symptoms, thoracic radiology and mediastinal lymph node biopsy results were in keeping with sarcoidosis as the underlying cause of this multisystem presentation. Corticosteroids were commenced with clinical and biochemical improvement. This novel case highlights the need to consider sarcoidosis as part of the differential diagnosis for unusual multiorgan presentations and for early multidisciplinary involvement in such cases to permit optimal treatment.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

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